A two -month column that offers a well -founded insight into the latest state -of -the -art progress in gynecology and health of women through experts in the reproductive health of women.
The concept of the DE outlet has recorded public imagination in recent years, whereby ambitious projects aim to revive species such as woolen mammoth through advanced genetic technologies. The wool mouse, a laboratory hybrid model with unique hair follicle properties, also contributed to our understanding of the techniques of developmental biology and genetic engineering. These resurrection projects, although they concentrate on the protection of wild animals, concentrate parallels in the field of reproductive medicine, where scientists work to “resume” fertility and to preserve the reproductive potential for women who face medical challenges.
Dr. Nahla Kazim
Consultant reproductive and
Medicine and infertility
Founder, CEO by Kazims Fertility Barza
Just as researchers use the CrisPR technology to edit the elephants -DNA with mammoth genes, reproduction specialists, such as genes processing, can address infertility, genetic diseases and the preservation of fertility in women. The same precision that Woll Mammut could one day could possibly repair or permanently remove genetic mutations that cause conditions such as premature ovarian failure or hereditary reproductive cancer.
Processing for the reproductive health of women
This interface of de-extreme science and health of women represents a fascinating border on which technologies that have been developed for a purpose can completely change a different field. While we are researching these scientific boundaries, we have to consider how innovations that are intended for protection ultimately improve human reproductive options and previously accept incurable diseases that affect women.
Traditional gene editing methods such as zinc finger nuclases (ZFNS) and Talens had to develop user-defined proteins for every DNA target-a slower and expensive process. CRISPR-CAS9 revolutionized this field by acting as molecular “scissors” that RNA led in exact genomic places. This system is faster, cheaper and more precise and enables the changes in days than months.
Applications in reproductive medicine
Embryo processing: Crispr enables researchers to correct the disease-causing mutations in embryos before implantation, including structural and numerical chromosomal anomalies such as Down syndrome
Keimbahn cells: The editing of sperm, eggs or their precursor cells could remove hereditary disorders such as cystic fibrosis or sickle cell anemia from future generations.
Care of fertility: Crispr, inspired by the restoration of biological diversity, could theoretically restore functional gamets from somatic cells and offer hope without viable eggs or sperm. Crispr is also tested to repair genetic defects in eggs or ovarian fabric, which offers women with early ovarian failure or age -related infertility.
Endometriosis and PCOS: The gene processing could target hormonal paths and offer new therapeutic options for these frequent reproduction disorders.
Risks and dilemmata
Off-tart effects: Crispr can accidentally edit unintentional parts of the genome and cause off-tart mutations that can lead to chromosomal rearrangements or other genes. These errors can affect the safety and livelihood of edited embryos or gamets. These can lead to unforeseen health problems among individuals and their descendants, which is an important problem before clinical application.
Incomplete genome reconstruction: Crispr cannot generate exact replicas of extinct species or characteristics. Instead, it creates hybrids with partially restoring genetic features and raises questions about the reliability and functionality of the edited genomes.
Effects between the generations: The processing of germination genome changes the DNA in a way that can be handed over to future generations. This could eliminate hereditary diseases, but there is also a risk of transferring harmful changes or creating irreversible changes in the human gene pool, which causes concerns about long -term consequences and risks of developmental disorders.
Ethical limits of treatment compared to improvement: Genome processing for therapeutic purposes (e.g. holiness of infertility or genetic disorders) can be regarded as ethically acceptable than for the intentions of improvement (e.g. selection of characteristics such as intelligence, appearance or production of designer babies). The potential abuse of non -medical indications could lead to social inequality and a resolution of Eugenik, which emphasizes the need for robust bio -security measures.
Social and cultural implications: The genome processing calls on social norms about “naturalness” and raises concerns about “play of God”. Public awareness is important in order to build consensus on acceptable use of advanced health ranges and to enable them with balanced knowledge and at the same time maintain different cultural values.
Regulatory landscape: The lack of uniform international regulations on genome creates creates risks of unethical practices in jurisdiction with mild supervision. Worldwide, 70 countries prohibit the processing of the inheritable genome (changes that are handed over to descendants), while 11 limited research results allow. In the United Arab Emirates, the regulatory environment develops security and ethics to support innovative therapies at the same time. Initiatives under state -supported programs aim to integrate the latest technologies responsibly into health framework. Since January 2025 Screening Emirati Couples for 840 genetic conditions that enable informed family building options. The national genome strategy of the VAE aims to build a genetic database in order to lead personalized treatments and preventive care. The Ministry of Health regulates crispr-based therapies such as Casgevy as part of its robust gene editing frame and coordinates the global security standards and promotes treatments for blood disorders and other innovative therapies.
Balancing Hope & Responsibility
The potential of crispr in reproductive medicine is great, from the extincing heirloom to the expansion of the fertility windows or the restoration of the lost fertility. However, as a de-outlet projects, you remember manipulating manipulation of genetics humility and robust measures to combat unintentional consequences. For the United Arab Emirates and the world, the path is strict supervision, public dialogue and prioritization of security compared to speed.
If the woolen mice and mammoth emissions develop, we make sure that these projects do not endanger future generations.